KRAS Secondary Mutations That Confer Acquired Resistance to KRAS G12C Inhibitors, Sotorasib and Adagrasib, and Overcoming Strategies: Insights From In Vitro Experiments
T. Koga, Kenichi Suda, Toshio Fujino, Shuta Ohara, Akira Hamada, Masaya Nishino, Masato Chiba, Masaki Shimoji, Toshiki Takemoto, Takeo Arita, Michael Gmachl, Marco H. Hofmann, Junichi Soh, Tetsuya Mitsudomi
Topics & Concepts
KRASMedicineIn vitroComputational biologyCancer researchGeneticsInternal medicineBiologyCancerColorectal cancerProtein Kinase Regulation and GTPase SignalingPI3K/AKT/mTOR signaling in cancerReceptor Mechanisms and Signaling