Microbe-Metabolite Associations Linked to the Rebounding Murine Gut Microbiome Postcolonization with Vancomycin-Resistant Enterococcus faecium
Andre Mu, Glen P. Carter, Lucy Li, Nicole Isles, Alison Vrbanac, James T. Morton, Alan K. Jarmusch, David P. De Souza, Vinod K. Narayana, Komal Kanojia, Brunda Nijagal, Malcolm J. McConville, Rob Knight, Benjamin P. Howden, Timothy P. Stinear
Abstract
This study demonstrates the importance and power of linking bacterial composition profiling with metabolomics to find the interactions between commensal gut bacteria and a specific pathogen. Knowledge from this research will inform gut microbiome engineering strategies, with the aim of translating observations from animal models to human-relevant therapeutic applications.
Topics & Concepts
MicrobiomeMetabolite profilingGut microbiomeBiologyEnterococcus faeciumMetabolomicsMetaboliteComputational biologyMicrobiologyPathogenBacteriaBioinformaticsGeneticsAntibioticsBiochemistryGut microbiota and healthProbiotics and Fermented FoodsClostridium difficile and Clostridium perfringens research