Whole-exome sequencing reveals germline-mutated small cell lung cancer subtype with favorable response to DNA repair–targeted therapies
Camille Tlemsani, Nobuyuki Takahashi, Lőrinc Sándor Pongor, Vinodh N. Rajapakse, Manoj Tyagi, Xinyu Wen, Grace‐Ann Fasaye, Keith T. Schmidt, Parth Desai, Chul Kim, Arun Rajan, Shannon Swift, Linda Sciuto, Rasa Vilimas, Santhana Webb, Samantha Nichols, William D. Figg, Yves Pommier, Kathleen Calzone, Seth M. Steinberg, Jun S. Wei, Udayan Guha, Clesson Turner, Javed Khan, Anish Thomas
Abstract
), a homologous recombination-related gene, using agents synthetically lethal with homologous recombination deficiency, resulted in a notable disease response. This work demonstrates that SCLC, currently thought to result almost exclusively from tobacco exposure, may have an inherited predisposition and lays the groundwork for targeted therapies based on the genes involved.