Cellular resistance to an oncolytic virus is driven by chronic activation of innate immunity
Alejandra Larrieux, Rafael Sanjuán
Abstract
, suggesting novel functions for these genes. Transcriptomic changes associated to VSV resistance were similar among B16 clones and in some clones derived from the mouse colon carcinoma cell line CT26, suggesting that oncolytic virus resistance involves certain conserved mechanisms and is therefore a potentially predictable process.
Topics & Concepts
Oncolytic virusVesicular stomatitis virusBiologySindbis virusInnate immune systemVirusVirologyInterferonTranscriptomeImmunityGeneVirotherapyRIG-IImmunologyGene expressionGeneticsImmune systemRNAVirus-based gene therapy researchAnimal Virus Infections StudiesHerpesvirus Infections and Treatments