MnO<sub>2</sub>/Ce6 microbubble-mediated hypoxia modulation for enhancing sono-photodynamic therapy against triple negative breast cancer
Ping Li, Xiao Tan, Qing Dan, Azhen Hu, Zhengming Hu, Xiaoting Yang, Jianhua Bai, Xiaoyu Chen, Bowei Li, Guanxun Cheng, Li Liu, Yun Chen, Desheng Sun, Xintao Shuai, Tingting Zheng
Abstract
/Ce6@MBs combined with SPDT significantly reversed tumor hypoxia and inhibited tumor growth in 4T1-tumor bearing mice. This work presents a theragnostic system for reversing tumor hypoxia and enhancing TNBC treatment.
Topics & Concepts
Triple-negative breast cancerPhotodynamic therapyCancer researchBreast cancerMedicineCancerHypoxia (environmental)OncologyInternal medicineChemistryOrganic chemistryOxygenNanoplatforms for cancer theranosticsPhotoacoustic and Ultrasonic ImagingUltrasound and Hyperthermia Applications