Access to SCF<sub>3</sub>-Substituted Indolizines via a Photocatalytic Late-Stage Functionalization Protocol
Kevin Klaus Stefanoni, René Wilhelm
Abstract
High Resolution Image Download MS PowerPoint Slide A mild, scalable, and highly chemoselective photocatalytic method was developed for direct indolizine functionalization with N -((trifluoromethyl)thio)saccharin, yielding high amounts of desired products while tolerating various functional groups. The photoredox catalyst employed offers a straightforward and inexpensive alternative to commercially available catalysts. Additionally, a 3-SCF 3 analogue of a histamine H3 receptor antagonist was synthesized with excellent yield, demonstrating the strategy’s potential in developing biologically relevant molecules.
Topics & Concepts
ChemistrySurface modificationPhotocatalysisProtocol (science)Combinatorial chemistryOrganic chemistryCatalysisPhysical chemistryPathologyAlternative medicineMedicineSynthesis and Reactivity of HeterocyclesCyclopropane Reaction MechanismsFluorine in Organic Chemistry