Antimicrobial α-defensins as multi-target inhibitors against amyloid formation and microbial infection
Yanxian Zhang, Yonglan Liu, Yijing Tang, Dong Zhang, Huacheng He, Jiang Wu, Jie Zheng
Abstract
β-structure interactions. The discovery of antimicrobial peptides containing β-structures to inhibit both microbial infection and amyloid aggregation greatly expands the new therapeutic potential of antimicrobial peptides as multi-target amyloid inhibitors for better understanding pathological causes and treatments of amyloid diseases.
Topics & Concepts
AntimicrobialAntimicrobial peptidesAmyloid (mycology)MicrobiologyBeta defensinChemistryBiologyInorganic chemistryAntimicrobial Peptides and ActivitiesProtein Hydrolysis and Bioactive PeptidesBiochemical and Structural Characterization