LARP1 and LARP4: up close with PABP for mRNA 3’ poly(A) protection and stabilization
Sandy Mattijssen, Guennadi Kozlov, Bruno D. Fonseca, Kalle Gehring, Richard J Maraia
Abstract
: 5'TOP: 5' terminal oligopyrimidine, LaM: La motif, LARP: La-related protein, LARP1: La-related protein 1, MLLE: mademoiselle, NTR: N-terminal region, PABP: cytoplasmic poly(A)-binding protein (PABPC1), Pol III: RNA polymerase III, PAM2: PABP-interacting motif 2, PB: processing body, RRM: RNA recognition motif, SG: stress granule.
Topics & Concepts
Poly(A)-binding proteinRNA recognition motifMessenger RNABiologyRNA-binding proteinRNACell biologyPolyadenylationMolecular biologyGeneticsGeneRNA Research and SplicingViral Infections and Immunology ResearchRNA and protein synthesis mechanisms