PP9, a steroidal saponin, induces G2/M arrest and apoptosis in human colorectal cancer cells by inhibiting the PI3K/Akt/GSK3β pathway
Minna Yao, Ruili Li, Zhifu Yang, Yi Ding, Wei Zhang, Weiwei Li, Meiyou Liu, Chao Zhao, Yanhua Wang, Haifeng Tang, Jingwen Wang, Aidong Wen
Topics & Concepts
PI3K/AKT/mTOR pathwayProtein kinase BApoptosisLY294002Cyclin-dependent kinase 1Cancer researchCell cycle checkpointChemistryDownregulation and upregulationColorectal cancerCyclin B1Cell cycleMedicineCancerInternal medicineBiochemistryGenePhytochemical Studies and BioactivitiesNatural product bioactivities and synthesisCell death mechanisms and regulation