Targeted protein degradation via the autophagy-lysosome system: AUTOTAC (AUTOphagy-TArgeting Chimera)
Chang Hoon Ji, Min Ju Lee, Hee Yeon Kim, Ah Jung Heo, Daniel Youngjae Park, Yun Kyung Kim, Bo Yeon Kim, Yong Tae Kwon
Abstract
. We suggest that AUTOTAC provides a platform for selective proteolysis as a research tool and in drug development.
Topics & Concepts
AutophagySequestosome 1LysosomeBiologyCell biologyProtein degradationBAG3ProteasomeProteolysisNeurodegenerationChimera (genetics)Protein aggregationAutophagosomeBiochemistryEnzymeMedicineDiseaseGenePathologyApoptosisAutophagy in Disease and TherapyProtein Degradation and InhibitorsUbiquitin and proteasome pathways