Snake extract–laden hemostatic bioadhesive gel cross-linked by visible light
Yicheng Guo, Ying Wang, Xiaohong Zhao, Xue Li, Quan Wang, Wen Zhong, Kibret Mequanint, Rixing Zhan, Malcolm Xing, Gaoxing Luo
Abstract
HAD leads to the activation and aggregation of platelets and efficiently transforms fibrinogen into fibrin to achieve rapid hemostasis and seal the tissue. Blood clotting time with HAD was about 45 s compared with 5 to 6 min without HAD. HAD instantaneously achieved hemostasis on liver incision (~45 s) and cut rat tail (~34 s) and reduced blood loss by 79 and 78%, respectively. HAD is also efficient in sealing severely injured liver and abdominal aorta. HAD has great potential to bridge injured tissues by combing hemostasis with adhesives.
Topics & Concepts
HemostasisBioadhesiveFibrinClotting timeHemostatic AgentPlateletMedicineSurgeryChemistryBiomedical engineeringInternal medicineImmunologyPolymerOrganic chemistryHemostasis and retained surgical itemsSurgical Sutures and AdhesivesPolymer Surface Interaction Studies