Inhibitory signaling sustains a distinct early memory CD8 <sup>+</sup> T cell precursor that is resistant to DNA damage
Jonathan B. Johnnidis, Yuki Muroyama, Shin Foong Ngiow, Zeyu Chen, Sasikanth Manne, Zhangying Cai, Shufei Song, Jesse M. Platt, Jason M. Schenkel, Mohamed S. Abdel-Hakeem, Jean‐Christophe Beltra, Allison R. Greenplate, Mohammed-Alkhatim A. Ali, Kito Nzingha, Josephine R. Giles, Christelle Harly, John Attanasio, Kristen E. Pauken, Bertram Bengsch, Michael Paley, Vesselin T. Tomov, Makoto Kurachi, Dario A.A. Vignali, Arlene H. Sharpe, Steven L. Reiner, Avinash Bhandoola, F. Bradley Johnson, E. John Wherry
Abstract
An early memory CD8 + T cell precursor with distinct genome maintenance capacity depends on inhibitory receptor signaling.
Topics & Concepts
DNADNA damageInhibitory postsynaptic potentialCytotoxic T cellCD8Cell biologyBiologySignal transductionCellChemistryImmunologyCancer researchNeuroscienceImmune systemGeneticsIn vitroImmune Cell Function and InteractionT-cell and B-cell ImmunologyImmunotherapy and Immune Responses