Deoxygenative alkynylation of amides <i>via</i> CO bond cleavage
Lan Chen, Wei Zhou, Jianwen Zhang, Yi-min Ding, Michal Szostak, Chengwei Liu
Abstract
A novel deoxygenative alkynylation of amides promoted by a synergistic action of a divalent rare-earth element and a transition metal has been developed. In this method, α-alkynyl substituted amines are synthesized from unactivated amides and alkynes in a single transformation. Broad substrate scope and excellent selectivity for CO cleavage has been demonstrated. This approach represents a general method for the construction of versatile α-alkynyl substituted amines from unactivated amide bonds.
Topics & Concepts
AlkynylationBond cleavageChemistryCleavage (geology)StereochemistryMedicinal chemistryCombinatorial chemistryOrganic chemistryCatalysisBiologyFracture (geology)PaleontologyAdvanced Synthetic Organic ChemistryChemical synthesis and alkaloidsChemical Synthesis and Analysis