Reproductive Complications in Childhood Cancer Survivors
Hanneke M. van Santen, Marianne D. van de Wetering, Annelies M. E. Bos, Marry M. vd Heuvel-Eibrink, Helena J. H. van der Pal, William H. Wallace
Abstract
Gonadal dysfunction and infertility after cancer treatment are major concerns for childhood cancer survivors and their parents. Uncertainty about fertility or being diagnosed with infertility has a negative impact on quality of survival. In this article, determinants of gonadal damage are reviewed and consequences for fertility and pregnancies are discussed. Recommendations for screening and treatment of gonadal function are provided. These should enable timely treatment of gonadal insufficiency aiming to improve linear growth, pubertal development, and sexual functioning. Options for fertility preservation are discussed.