Litcius/Paper detail

537MO First-in-human study of JNJ-64619178, a protein arginine methyltransferase 5 (PRMT5) inhibitor, in patients with advanced cancers

M. Vieito Villar, Anna Spreafico, Víctor Moreno, Irene Braña, Tatiana Hernández, Albiruni Abdul Razak, J. Wang, Nahor Haddish‐Berhane, Jaydeep Mehta, Amy J. Johnson, Anke Maes, John L. Haslam, Pankaj Mistry, Anna Kalota, Laurie Lenox, Jon Infante, Matthew V. Lorenzi, Hong Xie, Josh Lauring, Manish R. Patel

2020Annals of Oncology31 citationsDOI

Topics & Concepts

MedicineNeutropeniaCmaxAdverse effectAnemiaInternal medicinePharmacodynamicsGastroenterologyPharmacokineticsDosingNauseaProtein arginine methyltransferase 5DysgeusiaOncologyToxicityPharmacologyMethyltransferaseChemistryBiochemistryMethylationGeneCancer-related gene regulation