537MO First-in-human study of JNJ-64619178, a protein arginine methyltransferase 5 (PRMT5) inhibitor, in patients with advanced cancers
M. Vieito Villar, Anna Spreafico, Víctor Moreno, Irene Braña, Tatiana Hernández, Albiruni Abdul Razak, J. Wang, Nahor Haddish‐Berhane, Jaydeep Mehta, Amy J. Johnson, Anke Maes, John L. Haslam, Pankaj Mistry, Anna Kalota, Laurie Lenox, Jon Infante, Matthew V. Lorenzi, Hong Xie, Josh Lauring, Manish R. Patel
Topics & Concepts
MedicineNeutropeniaCmaxAdverse effectAnemiaInternal medicinePharmacodynamicsGastroenterologyPharmacokineticsDosingNauseaProtein arginine methyltransferase 5DysgeusiaOncologyToxicityPharmacologyMethyltransferaseChemistryBiochemistryMethylationGeneCancer-related gene regulation