Molecular-dynamics-simulation-guided directed evolution of flavoenzymes for atroposelective desaturation
Hong-Ning Yin, Zhao Chen, Xiang Zhao, Zihan Liu, Feng Yu, Sanduo Zheng, Niu Huang, Zhen Liu, Zhen Liu, Zhen Liu
Topics & Concepts
ChemistryAtropisomerKinetic resolutionCombinatorial chemistryNatural productBiocatalysisBiochemical engineeringDirected evolutionSubstrate (aquarium)Directed Molecular EvolutionCatalysisMolecular dynamicsEnzymeReaction conditionsOrganic synthesisProcess (computing)Small moleculeYield (engineering)StereochemistryMoleculeComputational biologyMolecular modelScope (computer science)Enzyme catalysisSubstrate specificityStereoisomerismChemical synthesisAxial and Atropisomeric Chirality SynthesisMolecular spectroscopy and chiralityAlkaloids: synthesis and pharmacology