A self-amplified ROS-responsive chemodrug–inhibitor conjugate for multi-drug resistance tumor therapy
Tingting Sun, Jie Xu, Tianbao Chen, Chunlai Tu, Lijuan Zhu, Deyue Yan
Abstract
A self-amplified ROS-responsive nano-drug delivery system is constructed by assembly of precise drug-inhibitor conjugate, which can initiate the positive feedback loop for sustainable drug release and reversing MDR.
Topics & Concepts
ChemistryReactive oxygen speciesConjugateIn vivoCancer cellMultiple drug resistancePharmacologyTumor microenvironmentEndocytosisDrug deliveryCancer researchCancerBiochemistryBiologyTumor cellsReceptorAntibioticsGeneticsBiotechnologyOrganic chemistryMathematical analysisMathematicsNanoparticle-Based Drug DeliveryNanoplatforms for cancer theranosticsDrug Transport and Resistance Mechanisms