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Design, synthesis, biological evaluation and molecular docking study of novel chalcone-based hydroxamic acids possessing a central 2, 4-dimethy pyrrole linker as potential HDAC (Histone Deacetylase) inhibitors and anticancer agents

Mozhdeh Yousefian, Maryam Hashemi, Vahid Eskandarpour, Farzin Hadizadeh, Afshin Zarghi, Razieh Ghodsi

2024Journal of Molecular Structure14 citationsDOI

Topics & Concepts

ChemistryChalconeVorinostatHistone deacetylaseHydroxamic acidStereochemistryDocking (animal)MTT assayHistone deacetylase inhibitorIC50HeLaCytotoxicityBiochemistryCell growthIn vitroHistoneMedicineNursingGeneHistone Deacetylase Inhibitors ResearchClick Chemistry and ApplicationsProtein Degradation and Inhibitors
Design, synthesis, biological evaluation and molecular docking study of novel chalcone-based hydroxamic acids possessing a central 2, 4-dimethy pyrrole linker as potential HDAC (Histone Deacetylase) inhibitors and anticancer agents | Litcius