Hypoxia-preconditioned olfactory mucosa mesenchymal stem cells abolish cerebral ischemia/reperfusion-induced pyroptosis and apoptotic death of microglial cells by activating HIF-1α
Yan Huang, Fengbo Tan, Yi Zhuo, Jianyang Liu, Jialin He, Da Duan, Ming Lü, Zhiping Hu
Abstract
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Topics & Concepts
PyroptosisMesenchymal stem cellNeuroprotectionProgrammed cell deathCell biologyApoptosisHypoxia (environmental)Paracrine signallingMicrogliaImmunologyBiologyMedicinePharmacologyInflammationChemistryInternal medicineBiochemistryOrganic chemistryOxygenReceptorNeuroinflammation and Neurodegeneration MechanismsHydrogen's biological and therapeutic effectsMesenchymal stem cell research