Transition-metal-free radical difluorobenzylation/cyclization of unactivated alkenes: access to ArCF<sub>2</sub>-substituted ring-fused quinazolinones
Jinwei Yuan, Meiyue Zhang, Yan Liu, Wenyu Hu, Liangru Yang, Yongmei Xiao, Xiaoqiong Diao, Shouren Zhang, Jian Mao
Abstract
A mild and efficient transition metal-free radical difluoroarylmethylation/cyclization of unactivated alkenes toward the synthesis of quinazolinone derivatives with easily accessible α,α-difluoroarylacetic acids has been developed.
Topics & Concepts
ChemistryQuinazolinoneCombinatorial chemistryTransition metalRing (chemistry)RadicalScope (computer science)Organic chemistryCatalysisComputer scienceProgramming languageFluorine in Organic ChemistryQuinazolinone synthesis and applicationsN-Heterocyclic Carbenes in Organic and Inorganic Chemistry