Regenerating myofiber directs Tregs and Th17 responses in inflamed muscle through the intrinsic TGF-β signaling-mediated IL-6 production
Tao Huang, Jing-Wen Huang, Zhaohong Liao, Haiqiang Lan, Xiaoting Jian, Ruicai Gu, Jun Ouyang, Jijie Hu, Hua Liao
Abstract
Myofiber mediates muscle inflammatory response through activating the intrinsic TGF-β signaling. The specific TGF-β signaling activation contributes to myofiber IL-6 production and directs muscle-specific Th17 and Treg cell responses.
Topics & Concepts
MyocyteInflammationSkeletal muscleMyogenesisCytokineTransforming growth factorBiologyCell biologySignal transductionImmune systemEndocrinologyInternal medicineImmunologyMedicineMuscle Physiology and DisordersMesenchymal stem cell researchExercise and Physiological Responses