mTORC1 directly inhibits AMPK to promote cell proliferation under nutrient stress
Naomi X.Y. Ling, Adrian Kaczmarek, Ashfaqul Hoque, Elizabeth A. Colby Davie, Kevin R. W. Ngoei, Kaitlin R. Morrison, William J. Smiles, Gabriella Forte, Tingting Wang, Shervi Lie, Toby A. Dite, Christopher G. Langendorf, John W. Scott, Jonathan S. Oakhill, Janni Petersen
Topics & Concepts
AMPKmTORC1Cell biologyNutrient sensingPhosphorylationProtein kinase AAMP-activated protein kinaseMechanistic target of rapamycinPI3K/AKT/mTOR pathwayCell growthSignal transductionBiologyKinaseChemistryBiochemistryMetabolism, Diabetes, and CancerPI3K/AKT/mTOR signaling in cancerPlant nutrient uptake and metabolism