Japanese Encephalitis Virus NS1′ Protein Interacts with Host CDK1 Protein to Regulate Antiviral Response
Qiuyan Li, Dengyuan Zhou, Fan Jia, Luping Zhang, Usama Ashraf, Yunchuan Li, Hongyu Duan, Yunfeng Song, Huanchun Chen, Shengbo Cao, Jing Ye
Abstract
Japanese encephalitis virus (JEV) is the main cause of acute human encephalitis in Asia. The unavailability of specific treatment for Japanese encephalitis demands a better understanding of the basic cellular mechanisms that contribute to the onset of disease. The present study identifies a novel interaction between the JEV NS1' protein and the cellular CDK1 protein, which facilitates the JEV replication by dampening the cellular antiviral response. This study sheds light on a novel mechanism of JEV replication, and thus our findings could be employed for developing new therapies against JEV infection.
Topics & Concepts
PhosphorylationBiologyCyclin-dependent kinase 1VirologyVirusJapanese encephalitisCREBInterferonImmune systemInnate immune systemDephosphorylationViral replicationRNA interferenceProtein kinase REncephalitisProtein phosphorylationmicroRNACell biologyProtein kinase AKinaseNeurotropic virusSignal transductionVenezuelan equine encephalitis virusMosquito-borne diseases and controlEndoplasmic Reticulum Stress and DiseaseCalcium signaling and nucleotide metabolism