Activation of PKM2 metabolically controls fulminant liver injury via restoration of pyruvate and reactivation of CDK1
Xiaohui Lv, Honghong Zhou, Kai Hu, Ling Lin, Yongqiang Yang, Longjiang Li, Li Tang, Jiayi Huang, Yi Shen, Rong Jiang, Jingyuan Wan, Zhang Li
Topics & Concepts
PKM2Pyruvate kinasePyruvate dehydrogenase complexPyruvate dehydrogenase kinasePyruvate decarboxylationPyruvate carboxylaseLiver injuryActivator (genetics)ChemistryPyruvate dehydrogenase phosphataseGlycolysisBiochemistryPharmacologyMetabolismMedicineEnzymeReceptorCancer, Hypoxia, and MetabolismMetabolism and Genetic DisordersMitochondrial Function and Pathology