What fuels the fly: Energy metabolism in <i>Drosophila</i> and its application to the study of obesity and diabetes
Nirmalya Chatterjee, Norbert Perrimon
Abstract
and mammals. We describe how these signaling pathways are regulated by several physiological and environmental cues to accommodate tissue-, age-, and environment-specific differences in energy demand. Last, we discuss several genetic and diet-induced fly models of obesity and diabetes that can be leveraged to better understand the molecular basis of these metabolic diseases and thereby promote the development of novel therapies.
Topics & Concepts
Drosophila melanogasterDiabetes mellitusDrosophila (subgenus)Energy metabolismOn the flyObesityBioinformaticsComputational biologyBiologyMedicineComputer scienceInternal medicineEndocrinologyBiochemistryGeneOperating systemNeurobiology and Insect Physiology ResearchGenetics, Aging, and Longevity in Model OrganismsPhysiological and biochemical adaptations