Modulating Schwann cell behavior via functional nerve guidance conduits for enhanced peripheral nerve regeneration
Keyue Yang, Shujian Yang, Xiaofeng Teng, Xinkun He, Tao Sun, Hong Chen
Abstract
Peripheral nerve injuries beyond 5 cm lack effective treatments. Functional nerve guidance conduits (NGCs) have emerged as transformative tools orchestrating regeneration by leveraging Schwann cell (SC)-centric mechanisms. This review comprehensively analyzes how NGC designs modulate SC behavior through three synergistic axes: physical cues, biochemical signaling, and bioelectric regulation. By enhancing microenvironmental regulation, next-generation NGCs aim to surpass autograft efficacy, offering scalable solutions for functional nerve recovery and improved patient outcomes.
Topics & Concepts
Regeneration (biology)Schwann cellPeripheral nerveNeuroscienceNerve guidance conduitPeripheral nerve injuryCellMedicineNerve repairNerve injuryPeripheralPeripheral nervous systemCell biologyBiologyAnatomyOlfactory ensheathing gliaCell therapyAxonStem cellCell bodiesCell survivalTissue engineeringEpineurial repairNerve injury and regenerationNeuroscience and Neural EngineeringNerve Injury and Rehabilitation