DNA methylation maintains the CLDN1-EPHB6-SLUG axis to enhance chemotherapeutic efficacy and inhibit lung cancer progression
Jia-En Wu, Yi-Ying Wu, Chia-Hao Tung, Yao‐Tsung Tsai, Hsuan‐Yu Chen, Yuh-Ling Chen, Tse-Ming Hong
Abstract
This study revealed that DNA methylation maintains CLDN1 expression and then represses lung cancer progression via the CLDN1-EPHB6-ERK1/2-SLUG axis. Because CLDN1 enhances the efficacy of chemotherapy, CLDN1 is not only a prognostic marker but a predictive marker for lung adenocarcinoma patients who are good candidates for chemotherapy. Forced CLDN1 expression in low CLDN1-expressing lung adenocarcinoma will increase the chemotherapy response, providing a novel therapeutic strategy.
Topics & Concepts
Trichostatin AChromatin immunoprecipitationCancer researchMetastasisCancer cellBiologyCancerDNA methylationSlugHistone deacetylaseChemistryHistoneGene expressionPromoterGeneticsGeneBarrier Structure and Function StudiesCancer-related molecular mechanisms researchCancer Cells and Metastasis