Synthesis and biological properties of maleimide-based macrocyclic lactone enediynes
Xiaoxuan Li, Haotian Lu, Mingming Ji, Ke Sun, Fangxu Pu, Yun Ding, Aiguo Hu
Abstract
an apoptosis pathway at low half inhibitory concentrations. Computational studies suggested that the maleimide moiety promoted the propargyl-allenyl rearrangement of the cyclic enediyne, enabling the generation of diradical species through the Myers-Saito cyclization, and then abstracted hydrogen atoms from the H-donors.
Topics & Concepts
ChemistryMaleimideLactoneCombinatorial chemistryStereochemistryOrganic chemistryCyclization and Aryne ChemistryCholinesterase and Neurodegenerative DiseasesPhytochemical compounds biological activities