Electrochemically Mediated Carboxylative Cyclization of Allylic/Homoallylic Amines with CO<sub>2</sub> at Ambient Pressure
Yong-Zhou Pan, Yong-Zhou Pan, Qiang Xia, Jinxiu Zhu, Ying‐Chun Wang, Ying Liang, Heng‐Shan Wang, Haitao Tang, Ying-Ming Pan, Ying-Ming Pan
Abstract
CO2 is an important C1 resource. We report a method for the synthesis of pharmacologically active 2-oxazolidinones by reacting CO2 with allylic amines. As opposed to previous addition reactions, the unsaturated double bonds are preserved. Thus, the product is more plastic and easier to use for subsequent structural modification. Furthermore, this method can also be applied to the synthesis of six-membered heterocycles (1,3-oxazinan-2-ones) and the participation of a low concentration of CO2, indicating it has certain practicability.
Topics & Concepts
Allylic rearrangementChemistryCombinatorial chemistryDouble bondAmbient pressureMedicinal chemistryOrganic chemistryCatalysisThermodynamicsPhysicsCarbon dioxide utilization in catalysisCO2 Reduction Techniques and CatalystsAsymmetric Hydrogenation and Catalysis