Development and validation of a sensitive LC-MS/MS method for pioglitazone: application towards pharmacokinetic and tissue distribution study in rats
Kusuma Kumari G., Praveen Thaggikuppe Krishnamurthy, Ravi Kiran Ammu V. V. V., Vishwanath Kurawattimath, S. T. Narenderan, B. Babu, Nagappan Krishnaveni
Abstract
was highest in plasma (5.62 ± 0.74 h) and lowest in kidney (2.78 ± 0.19). The developed method was successfully used to measure the PGZ pharmacokinetic and tissue distribution. Further, the developed method could be utilized for validating target organ (adipose tissue) specific delivery of PGZ (nano-formulations) in addition to conventional dosage forms.
Topics & Concepts
PioglitazonePharmacokineticsDistribution (mathematics)Tissue distributionChemistryPharmacologyChromatographyMedicineInternal medicineMathematicsEndocrinologyDiabetes mellitusMathematical analysisType 2 diabetesAnalytical Methods in PharmaceuticalsReceptor Mechanisms and SignalingAnalytical Chemistry and Chromatography