Hybrids of delavirdine and piperdin-4-yl-aminopyrimidines (DPAPYs) as potent HIV-1 NNRTIs: Design, synthesis and biological activities
Wei Ming, Wenlong Lu, Christophe Pannecouque, Jiong Chen, Haifeng Wang, Ya-Qi Xiao, Sha Hu, Shuang‐Xi Gu, Yuan‐Yuan Zhu, Fen‐Er Chen, Fen‐Er Chen
Topics & Concepts
ChemistryPotencyEC50IC50MutantStereochemistryHuman immunodeficiency virus (HIV)Reverse transcriptaseIn vitroStructure–activity relationshipBiochemistryVirologyGeneBiologyRNAHIV/AIDS drug development and treatmentHIV Research and TreatmentPneumocystis jirovecii pneumonia detection and treatment