Protective manifestation of herbonanoceuticals as antifungals: A possible drug candidate for dermatophytic infection
Anusha Sharma, Sarika Gupta
Abstract
Background and Aims: Fungal dermatophytosis or Tinea is a predominance in about 20%-25% of all total world populations. Dermatophyte infections are mainly caused by fungi belonging to Trichophyton, Epidermophyton, and Microsporum genera along with some other fungi. This epidemiological distribution may change with migration, lifestyle, immunosuppressive state, drug therapy, and socioeconomic conditions. Methods: The present review indicated the bioefficacy of herbal and herbonanoconjugate as safe management of fungal dermatophytic infection. Results: It also emphasized the action mechanism as fungicidal and fungistatic with different harmful impacts indicating the need for alternative therapeutics. Simultaneously, the herbal and herbonanoconjugate approaches proved better to manage the prevalence of hepatotoxicity, nephrotoxicity, nausea, altered taste, anemia, GI upsets, hair loss, and so forth. due to conventional oral treatment approaches. Conclusion: Adoption of the remedial approach can be recommended after preclinical trials' approval as a safe treatment.