Organ burden of inhaled nanoceria in a 2-year low-dose exposure study: dump or depot?
Jutta Tentschert, Peter Laux, Harald Jungnickel, Josephine Brunner, Irina Estrela‐Lopis, Carolin Merker, Jan Meijer, Heinrich Ernst, Lan Ma‐Hock, Jana Keller, Robert Landsiedel, Andreas Luch
Abstract
burden per tissue decreased from lungs > lymph nodes > hard bone > liver > bone marrow. For two dosage groups, the liver organ burden showed a low accumulation rate. Here, the liver can be regarded as depot, whereas kidneys, the skeleton, and bone marrow seem to be dumps due to steadily increasing NP burden over time.
Topics & Concepts
LungLymphInhalationMedicineBone marrowIn vivoPathologyPhysiologyToxicityInternal medicineAnesthesiaBiologyBiotechnologyNanoparticles: synthesis and applicationsAir Quality and Health ImpactsInhalation and Respiratory Drug Delivery