Metallothionein-1G suppresses pancreatic cancer cell stemness by limiting activin A secretion <i>via</i> NF-κB inhibition
Kai Li, Zhicheng Zhang, Yu Mei, Qingzhu Yang, Shupei Qiao, Cheng Ni, Yao Yao, Xinyuan Li, Mengmeng Li, Dongdong Wei, Wangjun Fu, Xuefei Guo, Xuemei Huang, Huanjie Yang
Abstract
NF-κB inhibition. The blockade of the activin A signaling with follistatin may provide a promising therapeutic strategy for overcoming gemcitabine resistance in PDAC.
Topics & Concepts
FollistatinPancreatic cancerCancer researchGemcitabineCancer stem cellDownregulation and upregulationChemistryCancerBiologyEndocrinologyInternal medicineMedicineGeneBiochemistryTGF-β signaling in diseasesTrace Elements in HealthBone Metabolism and Diseases