Congenital biliary atresia is correlated with disrupted cell junctions and polarity caused by Cdc42 insufficiency in the liver
Yongjie Zhou, Hongjie Ji, Qing Xu, Xiaoyun Zhang, Xiaoyue Cao, Yuwei Chen, Mingyang Shao, Zhenru Wu, Jie Zhang, Changli Lu, Jiayin Yang, Yujun Shi, Hong Bu
Abstract
Our results illustrate that BA is closely correlated with the impaired assembly of cell junction and polarity complexes in liver cells, which is likely caused by Cdc42 insufficiency and aggravated by bile acid corrosion.
Topics & Concepts
Biliary atresiaPolarity (international relations)CDC42Cell polarityCell biologyAtresiaCellMedicineBiologyInternal medicineChemistryPathologyBiochemistryActinLiver transplantationTransplantationPediatric Hepatobiliary Diseases and TreatmentsInfant Nutrition and HealthCongenital Anomalies and Fetal Surgery