But-3-ene-1,3-disulfonyl difluoride (BDF): a highly selective SuFEx clickable hub for the quick assembly of sultam-containing aliphatic sulfonyl fluorides
Chen Li, Yujie Zheng, K.P. Rakesh, Hua‐Li Qin
Abstract
A versatile selectively addressable SuFEx click chemistry hub, but-3-ene-1,3-disulfonyl difluoride (BDF) was designed and synthesized through head-to-tail dimerization of ethenesulfonyl fluoride (ESF). BDF possesses three active sites to selectively participate in the construction of 4-membered, 5-membered and 6-membered cyclic sulfonamide (sultams) bearing aliphatic sulfonyl fluoride moieties for further manipulations in a fast, efficient and practical manner.
Topics & Concepts
SulfonylChemistryEne reactionDifluorideOrganic chemistryCombinatorial chemistryAlkylOrganic and Inorganic Chemical ReactionsFluorine in Organic ChemistryCarbohydrate Chemistry and Synthesis