Design, synthesis, and evaluation of pyrrolidine based CXCR4 antagonists with in vivo anti-tumor metastatic activity
Zhanhui Li, Xu Wang, Lin Yu, Yujie Wang, S. C. Wu, Kaijiang Xia, Xu Chen, Haikuo Ma, Jiyue Zheng, Lusong Luo, Fang Zhu, Sudan He, Xiaohu Zhang
Topics & Concepts
ChemistryIn vivohERGPharmacologyPyrrolidineMetastasisIn vitroIC50CXCR4Chemokine receptorCXCR4 antagonistReceptorBiochemistryChemokineCancer researchCancerStereochemistryBiophysicsBiologyMedicinePotassium channelInternal medicineBiotechnologyChemokine receptors and signalingMultiple Myeloma Research and TreatmentsImmunotherapy and Immune Responses