Magnetic Nanoparticles as Green Catalysts for Isatin Derivative Synthesis: Mechanistic Insights and Sustainability
Divya Gaur, Shubham Sharma, Prabal Pratap Singh, Bhavana Sharma, Kaushiki Mishra, Alka Gautam
Abstract
Abstract Green synthetic techniques have become highly significant in modern organic chemistry because of their potency, sustainability, and smaller environmental consequences. In this context, magnetic nanoparticles (MNPs) have emerged as highly attractive and versatile catalysts due to their significant active surface area, ease of magnetic separation from reaction fluids, reusability, and the ability to customize surface modifications. The use of MNPs as eco‐friendly catalytic systems for the synthesis of heterocyclic frameworks has attracted a lot of attention. Among heterocyclic compounds, isatin derivatives are prized for their flexibility in biomedical research and pharmaceutical development. MNPs have shown their potential in the development of various interesting istain‐based molecular architectures. In this review, we have highlighted the underlying mechanistic features, catalytic benefits, and sustainability viewpoints of the recent developments in the MNP‐assisted synthesis of isatin and its derivatives. This is the first report that highlights the significant role of MNPs toward the formation of isatin‐based molecular hybrids.