Control of the antitumour activity and specificity of CAR T cells via organic adapters covalently tethering the CAR to tumour cells
А. В. Степанов, Jia Xie, Qiaoqiao Zhu, Zuyuan Shen, Wenji Su, Letian Kuai, Richard Söll, Christoph Rader, Geramie Shaver, Lacey Douthit, Ding Zhang, R. S. Kalinin, Xiang Fu, Yingying Zhao, Tian Qin, Phil S. Baran, Alexander G. Gabibov, David Bushnell, Dario Neri, Roger D. Kornberg, Richard A. Lerner
Topics & Concepts
HaptenCytotoxicityAntigenChemistryAdapter (computing)Cytotoxic T cellCovalent bondSmall moleculeAntibodyChimeric antigen receptorIn vitroMolecular biologyCell biologyCancer researchBiologyT cellBiochemistryImmunologyImmune systemElectrical engineeringEngineeringOrganic chemistryCAR-T cell therapy researchMonoclonal and Polyclonal Antibodies ResearchNanowire Synthesis and Applications