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A highly-specific fully-human antibody and CAR-T cells targeting CD66e/CEACAM5 are cytotoxic for CD66e-expressing cancer cells in vitro and in vivo

Du-San Baek, Ye‐Jin Kim, Sandra Vergara, Alex Conard, Cynthia Adams, Guillermo Calero, Rieko Ishima, John W. Mellors, Dimiter S. Dimitrov

2021Cancer Letters33 citationsDOI

Topics & Concepts

Prostate cancerCancer researchAntibody-dependent cell-mediated cytotoxicityCytotoxic T cellCancer cellMonoclonal antibodyAntigenAntibodyIn vitroIn vivoBiologyCancerImmunologyChemistryBiochemistryBiotechnologyGeneticsCAR-T cell therapy researchRadiopharmaceutical Chemistry and ApplicationsMonoclonal and Polyclonal Antibodies Research
A highly-specific fully-human antibody and CAR-T cells targeting CD66e/CEACAM5 are cytotoxic for CD66e-expressing cancer cells in vitro and in vivo | Litcius