Solubility Measurement and Various Solubility Parameters of Glipizide in Different Neat Solvents
Mohd Abul Kalam, Aws Alshamsan, Musaed Alkholief, Ibrahim A. Alsarra, Raisuddin Ali, Nazrul Haq, Md. Khalid Anwer, Faiyaz Shakeel
Abstract
= 318.2 K". All investigated solubility parameters of GLZ were recorded very close to the DMSO. "Apparent thermodynamic analysis" showed an "endothermic and entropy-driven dissolution" of GLZ in the 12 different neat solvents. The highest molecular interactions were recorded in GLZ-DMSO compared to other combinations. Overall, DMSO has been considered as the best solvent for the solubilization of GLZ.
Topics & Concepts
SolubilityEthylene glycolSolventChemistryDissolutionMethanolGlipizideDimethyl sulfoxideNuclear chemistryPolyvinyl alcoholMole fractionEthyl acetateHildebrand solubility parameterChromatographyOrganic chemistryPhysical chemistryMedicineDiabetes mellitusEndocrinologyCrystallization and Solubility StudiesAnalytical Chemistry and ChromatographyPharmacological Effects of Natural Compounds