Metformin induces mitochondrial fission and reduces energy metabolism by targeting respiratory chain complex I in hepatic stellate cells to reverse liver fibrosis
Ying Su, Chenjian Hou, Meili Wang, Kehan Ren, Danmei Zhou, Xiaoli Liu, Xiaoli Liu, Shanyu Zhao, Xiuping Liu, Xiuping Liu
Topics & Concepts
MetforminHepatic stellate cellMitochondrial respiratory chainMitochondrial fissionMitochondrial DNAMitochondrionCell biologyRespiratory chainBiologyOxidative phosphorylationDownregulation and upregulationMitochondrial ROSChemistryCancer researchEndocrinologyBiochemistryGeneInsulinLiver Disease Diagnosis and TreatmentLiver physiology and pathologyOrgan Transplantation Techniques and Outcomes