Melatonin does not reduce mortality in adult hospitalized patients with COVID-19: a multicenter retrospective observational study
Marina Sánchez‐Rico, Pedro de la Muela, Juan José Herrera-Morueco, Pierre A. Geoffroy, Frédéric Limosin, Nicolas Hoertel
Abstract
In this multicenter retrospective observational study involving 58 562 adult patients hospitalized for COVID-19, melatonin use (N = 272) at a mean daily dose of 2.6 mg was not associated with reduced mortality.
Topics & Concepts
MedicineObservational studyRetrospective cohort studyMulticenter studyCoronavirus disease 2019 (COVID-19)Melatonin2019-20 coronavirus outbreakSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Internal medicinePediatricsRandomized controlled trialVirologyDiseaseOutbreakInfectious disease (medical specialty)Circadian rhythm and melatoninCOVID-19 and Mental HealthLong-Term Effects of COVID-19