A novel GSH depletor for simultaneous ferroptosis and cuproptosis Activation in hepatocellular carcinoma
Haoyu Yang, Xin Chen, Siqi Huang, Hongfang Dai, Zuowei Xiao, Jialong Fan, Honggang Zhang, Ke Du, Qin Yan
Topics & Concepts
GlutathioneChemistryGPX4In vitroLipid peroxidationCurcuminBiochemistryActivator (genetics)Cancer researchCell cultureCell biologyReactive oxygen speciesMitochondrionProgrammed cell deathCell growthHepatocellular carcinomaOxidative stressCellApoptosisCancer cellPharmacologyHepatocyteIn vivoCytosolFerroptosis and cancer prognosisSulfur Compounds in BiologyImmune cells in cancer