Nanosuspensions - An Update on Recent Patents, Methods of Preparation, and Evaluation Parameters
Harpreet Kaur Khanuja, Rajendra Awasthi, Meenu Mehta, Saurabh Satija, Alaa A. A. Aljabali, Murtaza M. Tambuwala, Dinesh Kumar Chellappan, Kamal Dua, Harish Dureja
Abstract
BACKGROUND: Nanosuspensions are colloidal systems consisting of pure drug and stabilizers, without matrix or lyophilized into a solid matrix. Nanosuspensions improve the solubility of the drug both in the aqueous and organic phases. Nanosuspensions are also known as brick dust molecules, as they increase the dissolution of a system and improve absorption. METHODS: Extensive information related to nanosuspensions and its associated patents were collected using Pub Med and Google Scholar. RESULTS: Over the last decade nanosuspensions have attracted tremendous interest in pharmaceutical research. It provides unique features including, improved solubility, high drug loading capacity, and passive targeting. These particles are cost-effective, simple, and have lesser side effects with minimal dose requirements. However, the stability of nanosuspensions still warrants attention. CONCLUSION: Nanosuspensions play a vital role in handling the numerous drug entities with difficult physico-chemical characteristics such as solubility and can further aid with a range of routes that include nasal, transdermal, ocular, parenteral, pulmonary etc. This review highlights the relevance of nanosuspensions in achieving safe, effective and targeted drug delivery.