A topological switch in CFTR modulates channel activity and sensitivity to unfolding
Daniel Scholl, Maud Sigoillot, Marie Overtus, Rafael Colomer Martinez, Chloé Martens, Yiting Wang, Els Pardon, Toon Laeremans, Abel García-Pino, Jan Steyaert, David N. Sheppard, Jelle Hendrix, Cédric Govaerts
Topics & Concepts
Cystic fibrosis transmembrane conductance regulatorCyclic nucleotide-binding domainChemistryFörster resonance energy transferBiophysicsTransmembrane domainRegulatorMutationCystic fibrosisIon channelTransmembrane proteinConformational changeMutantProtein structureCell biologyNucleotideBiochemistryBiologyGeneGeneticsFluorescenceReceptorPhysicsQuantum mechanicsCystic Fibrosis Research AdvancesAdvanced biosensing and bioanalysis techniquesNeonatal Respiratory Health Research