Dimeric Manganese‐Catalyzed Hydroarylation and Hydroalkenylation of Unsaturated Amides
Dongping Wang, Jie Dong, Wenjing Fan, Xiang‐Ai Yuan, Jian Han, Jin Xie
Abstract
An unprecedented Mn(I)-catalyzed selective hydroarylation and hydroalkenylation of unsaturated amides with commercially available organic boronic acids is reported. Alkenyl boronic acids have been successfully employed for the first time in Mn(I)-catalyzed carbon-carbon bond formation. A wide array of β-alkenylated amide products can be obtained in moderate to good yields, which offers practical access to five- and six-membered lactams. This protocol has predictable regio- and chemoselectivity, excellent functional group compatibility and ease of operation in air, representing a significant step-forward towards manganese-catalyzed C-C coupling.
Topics & Concepts
ChemoselectivityManganeseCatalysisAmideChemistryFunctional groupCombinatorial chemistryOrganic chemistryPolymerCatalytic C–H Functionalization MethodsAdvanced Synthetic Organic ChemistryAsymmetric Hydrogenation and Catalysis