Cooperation of the IFT-A complex with the IFT-B complex is required for ciliary retrograde protein trafficking and GPCR import
Takuya Kobayashi, Yamato Ishida, Tomoaki Hirano, Yohei Katoh, Kazuhisa Nakayama
Abstract
Little is known about how the IFT-A and IFT-B complexes of the intraflagellar transport machinery cooperate to mediate ciliary protein trafficking. We show that IFT144-IFT122 and IFT88-IFT52-IFT46 contribute to the IFT-A-IFT-B interface and that the interaction of IFT-A with IFT-B is required for retrograde trafficking of the IFT machinery and ciliary entry of G protein-coupled receptors.
Topics & Concepts
Intraflagellar transportCiliumBiologyCell biologyG protein-coupled receptorTransport proteinSignal transductionFlagellumBiochemistryGeneGenetic and Kidney Cyst DiseasesProtist diversity and phylogenyFetal and Pediatric Neurological Disorders