Monoacylglycerol lipase deficiency in the tumor microenvironment slows tumor growth in non-small cell lung cancer
Melanie Kienzl, Carina Hasenoehrl, Kathrin Maitz, Arailym Sarsembayeva, Ulrike Taschler, Paulina Valadez-Cosmes, Oliver Kindler, Dušica Ristić, Sofia Raftopoulou, Ana Santiso, Thomas Bärnthaler, Luka Brčić, Lisa Hahnefeld, Robert Gurke, Dominique Thomas, Gerd Geißlinger, Julia Kargl, Rudolf Schicho
Abstract
. Our results suggest that next to cancer cell-derived MGL, TME cells expressing MGL are responsible for maintaining a pro-tumorigenic environment in tumors of NSCLC.
Topics & Concepts
Tumor microenvironmentCancer researchStromal cellCytotoxic T cellCD8BiologyCancerGranzyme BLung cancerCancer cellImmune systemImmunologyChemistryMedicineIn vitroPathologyTumor cellsBiochemistryGeneticsCannabis and Cannabinoid ResearchImmune Cell Function and InteractionDiet, Metabolism, and Disease