Litcius/Paper detail

Discovery of new carbonic anhydrase IX inhibitors as anticancer agents by toning the hydrophobic and hydrophilic rims of the active site to encounter the dual-tail approach

Haytham O. Tawfik, Andrea Petreni, Claudiu T. Supuran, Mervat H. El‐Hamamsy

2022European Journal of Medicinal Chemistry63 citationsDOIOpen Access PDF

Topics & Concepts

ChemistryCarbonic anhydraseActive siteMoietyCarbonic anhydrase IIStereochemistrySelectivityGene isoformZincIn vitroEnzymeCombinatorial chemistryBiochemistryCatalysisOrganic chemistryGeneEnzyme function and inhibitionSynthesis and Catalytic ReactionsCholinesterase and Neurodegenerative Diseases
Discovery of new carbonic anhydrase IX inhibitors as anticancer agents by toning the hydrophobic and hydrophilic rims of the active site to encounter the dual-tail approach | Litcius